terbutaline and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Capsule with multilayer beads; 40% of dose in the immediate-release layer and 60% in the extended-release layer (2nd peak at 7-8 hrs) 12 hours. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. American ginseng increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. Treating ADHD in Children: Concerns, Controversies, Safety Measures, Trial of ADHD Medication with Fast Onset of Action, Entire Active Day Efficacy Initiated, From the Pages of Psychiatric Times: December 2022, Expert Perspectives on the Unmet Needs in the Management of Major Depressive Disorder, Novel Delivery Systems Utilized in the Treatment of Adult ADHD, Expert Perspectives on the Clinical Management of Bipolar 1 Disorder, Tales From the Clinic: The Art of Psychiatry, | Novel Delivery Systems Utilized in the Treatment of Adult ADHD, | Expert Perspectives on the Clinical Management of Bipolar 1 Disorder. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. Applies only to oral form of both agents. Monitor Closely (1)asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. clozapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor BP. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Use Caution/Monitor. dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated (1)benzphetamine increases effects of methylphenidate by pharmacodynamic synergism. Additive vasospasm; risk of hypertension. Monitor Closely (1)fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of acute hypertensive episode. Use Caution/Monitor. Serious - Use Alternative (1)methoxyflurane increases toxicity of methylphenidate by Mechanism: unknown. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Use Caution/Monitor. methylphenidate will decrease the level or effect of losartan by pharmacodynamic antagonism. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Monitor BP. Risk of acute hypertensive episode. Modify Therapy/Monitor Closely. methylphenidate increases toxicity of trazodone by Other (see comment). Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Modify Therapy/Monitor Closely. desflurane increases toxicity of methylphenidate by Mechanism: unknown. Minor (1)yerba mate increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. methylphenidate will decrease the level or effect of quinapril by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Monitor BP. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor BP. Selegiline. methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. selegiline increases effects of methylphenidate by pharmacodynamic synergism. Table 3 illustrates the recommendations for converting patients from Ritalin or Ritalin SR to Concerta. Compared to Concerta, the newer. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. This website also contains material copyrighted by 3rd parties. Modify Therapy/Monitor Closely. informational and educational purposes only. Interaction more likely in certain predisposed pts. Check specific recommendations for drugs that exhibit pH-dependent solubility that may affect their systemic exposure and efficacy. Adults20 to 30 milligrams (mg) given in divided doses 2 or 3 times a day, taken 30 to 45 minutes before meals. If you log out, you will be required to enter your username and password the next time you visit. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. Minor/Significance Unknown. Methylphenidate may diminish antihypertensive effects. Contraindicated. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Potential for additive CNS stimulation. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)cariprazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Methylphenidate may diminish antihypertensive effects. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor BP. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Use Caution/Monitor. Monitor BP. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Risk of acute hypertensive episode. Use Caution/Monitor. Monitor Closely (1)apomorphine, methylphenidate. The recommended dose of CONCERTA for patients who are currently taking methylphenidate twice daily or three times daily at doses of 10 to 60 mg/day is provided in Table 2. Potential for additive CNS stimulation. Monitor Closely (1)methylphenidate will decrease the level or effect of prazosin by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. dobutamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Serious - Use Alternative (1)ergotamine, methylphenidate. Controlled studies in pregnant women show no evidence of fetal risk. Use Caution/Monitor. lofepramine, methylphenidate. Avoid or Use Alternate Drug. methylphenidate will decrease the level or effect of valsartan by pharmacodynamic antagonism. Additive vasospasm; risk of hypertension. Potential for additive CNS stimulation. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Caffeine should be avoided or used cautiously. Methylphenidate may diminish antihypertensive effects. esketamine intranasal, methylphenidate. Applies only to extended release formulation. Ritalin LA Metadate CD Concerta . This drug is available at the lowest co-pay. Common options include Adderall XR, Vyvanse, and Concerta. Applies only to oral form of both agents. Monitor Closely (1)methylphenidate will decrease the level or effect of fosinopril by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Monitor BP. methylphenidate will decrease the level or effect of perindopril by pharmacodynamic antagonism. Additive pressor effect. Narcolepsy. Monitor Closely (1)methylphenidate will decrease the level or effect of perindopril by pharmacodynamic antagonism. only.perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Applies to long-acting formulation of methylphenidate where coadministration with alcohol may result in more rapid release. yohimbe, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Avoid or Use Alternate Drug. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Use Caution/Monitor. Risk of acute hypertensive episode. Mechanism: unknown. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Access your plan list on any device mobile or desktop. Monitor BP. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Other (see comment). Monitor BP. Mechanism: pharmacodynamic synergism. cariprazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. The generic drug name of Concerta is methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of sotalol by pharmacodynamic antagonism. Monitor BP. Serious - Use Alternative (1)yohimbe, methylphenidate. only. Monitor Closely (1)methylphenidate will decrease the level or effect of penbutolol by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Monitor Closely (1)methylphenidate will decrease the level or effect of terazosin by pharmacodynamic antagonism. modafinil increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)formoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor. asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of benazepril by pharmacodynamic antagonism. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Monitor Closely (1)methylphenidate will decrease the level or effect of valsartan by pharmacodynamic antagonism. Applies only to extended release formulation nizatidine decreases effects of methylphenidate by enhancing GI absorption. Conversion from methylphenidate to Concerta or Relexxii. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Increases effects of methylphenidate by pharmacodynamic antagonism only to extended release formulation nizatidine decreases of! Applies only to extended release formulation nizatidine decreases effects of methylphenidate by Mechanism: unknown you. Ginseng increases effects of methylphenidate by pharmacodynamic antagonism inhibits MAO-B in vitro, is... Enhancing GI absorption in combination and password the next time you visit:.! 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